The meaningful use of electronic health records (EHR) continues to progress in the digital era with clinical decision support systems augmented by artificial intelligence. A priority in improving provider experience is to overcome information overload and reduce the cognitive burden so fewer medical errors and cognitive biases are introduced during patient care. One major type of medical error is diagnostic error due to systematic or predictable errors in judgment that rely on heuristics. The potential for clinical natural language processing (cNLP) to model diagnostic reasoning in humans with forward reasoning from data to diagnosis and potentially reduce the cognitive burden and medical error has not been investigated. Existing tasks to advance the science in cNLP have largely focused on information extraction and named entity recognition through classification tasks.

Computational models providing accurate estimates of their uncertainty are crucial for risk management associated with decision making in healthcare contexts. This is especially true since many state-of-the-art systems are trained using the data which has been labelled automatically (self-supervised mode) and tend to overfit. In this work, we investigate the quality of uncertainty estimates from a range of current state-of-the-art predictive models applied to the problem of observation detection in radiology reports. This problem remains understudied for Natural Language Processing in the healthcare domain. We demonstrate that Gaussian Processes (GPs) provide superior performance in quantifying the risks of 3 uncertainty labels based on the negative log predictive probability (NLPP) evaluation metric and mean maximum predicted confidence levels (MMPCL), whilst retaining strong predictive performance.

Effective triage is critical to mitigating the effect of increased volume by accurately determining patient acuity, need for resources, and establishing effective acuity-based patient prioritization. The purpose of this retrospective study was to determine whether historical EHR data can be extracted and synthesized with clinical natural language processing (C-NLP) and the latest ML algorithms (KATE) to produce highly accurate ESI predictive models. An ML model (KATE) for the triage process was developed using 166,175 patient encounters from two participating hospitals. The model was then tested against a gold set that was derived from a random sample of triage encounters at the study sites and correct acuity assignments were recorded by study clinicians using the Emergency Severity Index (ESI) standard as a guide. At the two study sites, KATE predicted accurate ESI acuity assignments 75.9% of the time, compared to nurses (59.8%) and average individual study clinicians (75.3%). KATE accuracy was 26.9% higher than the average nurse accuracy (p-value < 0.0001). On the boundary between ESI 2 and ESI 3 acuity assignments, which relates to the risk of decompensation, KATE was 93.2% higher with 80% accuracy, compared to triage nurses with 41.4% accuracy (p-value < 0.0001). KATE provides a triage acuity assignment substantially more accurate than the triage nurses in this study sample. KATE operates independently of contextual factors, unaffected by the external pressures that can cause under triage and may mitigate the racial and social biases that can negatively affect the accuracy of triage assignment. Future research should focus on the impact of KATE providing feedback to triage nurses in real time, KATEs impact on mortality and morbidity, ED throughput, resource optimization, and nursing outcomes.